Scientific studies conclude GMO feed causes organ disruption in animals

Wednesday, October 05, 2011 by: Jeffrey M. Smith – Natural News

(NaturalNews) A new paper reviewing data from 19 animal studies shows that consuming genetically modified (GM) corn or soybeans leads to significant organ disruptions in rats and mice, particularly in livers and kidneys ( “Other organs may be affected too, such as the heart and spleen, or blood cells,” stated the paper. In fact some of the animals fed genetically modified organisms had altered body weights, which is “a very good predictor of side effects in various organs.”

The GM soybean and corn varieties used in the feeding trials “constitute 83% of the commercialized GMOs” that are currently consumed by billions of people. While the findings may have serious ramifications for the human population, the authors demonstrate how a multitude of GMO-related health problems could easily pass undetected through the superficial and largely incompetent safety assessments that are used around the world.

The researchers, lead by French Professor Gilles-Eric Seralini, found that nearly 1 out of every 10 measured parameters in the studies, including blood and urine biochemistry, organ weights, and microscopic analyses, were significantly disrupted in the animals fed GMOs. The kidneys of males fared the worst, with 43.5% of all the changes. The liver of females followed, with 30.8%. The report, published in Environmental Sciences Europe on March 1, 2011, confirms that “several convergent data appear to indicate liver and kidney problems as end points of GMO diet effects.” The authors point out that livers and kidneys “are the major reactive organs” in cases of chronic food toxicity.

Feed’em longer!

One of the most glaring faults in the current regulatory regime is the short duration of animals feeding studies. The industry limits trials to 90 days at most, with some less than a month. Only two studies reviewed in this new publication were over 90 days — both were non-industry research.

Short studies could easily miss many serious effects of GMOs. It is well established that some pesticides and drugs, for example, can create effects that are passed on through generations, only showing up decades later. IN the case of the drug DES (diethylstilbestrol), “induced female genital cancers among other problems in the second generation.” The authors urge regulators to require long-term multi-generational studies, to “provide evidence of carcinogenic, developmental, hormonal, neural, and reproductive potential dysfunctions, as it does for pesticides or drugs.”

Pesticide Plants

Nearly all GM crops are described as “pesticide plants.” They either tolerate doses of weed killer, such as Roundup, or produce an insecticide called Bt-toxin. In both cases, the added toxin — weedkiller or bug killer — is found inside the corn or soybeans we consume.

When regulators evaluate the toxic effects of pesticides, they typically require studies using three types of animals, with at least one feeding trial lasting 2 years or more. One third or more of the side effects produced by these toxins will show up only in the longer study — not the shorter ones. But for no good reason, regulators ignore the lessons learned from pesticides and waive the GM crops-containing-pesticides onto the market with a single species tested for just 90 days. The authors affirm that “it is impossible, within only 13 weeks, to conclude about the kind of pathology that could be induced by pesticide GMOs and whether it is a major pathology or a minor one. It is therefore necessary to prolong the tests.”

GMO approvals also ignore the new understanding that toxins don’t always follow a linear dose-response. Sometimes a smaller amount of toxins have greater impact than larger doses. Approvals also overlook the fact that mixtures can be far more dangerous than single chemicals acting alone. Roundup residues, for example, have been “shown to be toxic for human placental, embryonic, and umbilical cord cells,” whereas Roundup’s active ingredient glyphosate does not on its own provoke the same degree of damage. One reason for this is that the chemicals in Roundup “stabilize glyphosate and allow its penetration into cells.”

Furthermore, toxins may generate new substances (metabolites) “either in the GM plant or in the animals fed with it.” Current assessments completely ignore the potential danger from these new components in our diets, such as the “new metabolites” in GMOs engineered to withstand Roundup. The authors warn, “We consider this as a major oversight in the present regulations.”

“It’s not the same stuff that farmers spray”

Regulators claim that the Bt-toxin produced inside GM corn is safe. They say that the Bt gene comes from soil bacteria Bacillus thuringiensis (Bt), which has been safely applied as a spray-on insecticide by farmers in the past. But the authors insist that “the argument about ‘safe use history’ of the wild Bt protein . . . Cannot, on a sound scientific basis, be used for direct authorizations of . . . GM corns,” without conducting proper long-term animal feeding studies.

In order to justify their claim that the wild Bt-toxin is safe, the authors state that it must first be separately tested on animals and humans and then authorized individually for food or feed, which it has not. And even if the wild variety had been confirmed as safe, the GM versions are so different, they must require their own independent studies. The paper states:

“The Bt toxins in GMOs are new and modified, truncated, or chimerical in order to change their activities/solubility in comparison to wild Bt. For instance, there is at least a 40% difference between the toxin in Bt176 [corn] and its wild counterpart.”

Even though the isolated Bt-toxin from GM corn has not been tested on animals, rodent studies on corn containing the toxin do show problems. Male rats fed Monsanto’s MON863 corn, for example, had smaller kidneys with more focal inflammation and other “disrupted biochemical markers typical of kidney filtration or function problems.”

Stop with the dumb excuses

If statistically significant problems show up in their studies, biotech company researchers often attempt to explain away the adverse findings. But the authors of this review paper describe their excuses as unscientific, obsolete, or unjustified.

When male and female animals have different results, for example, biotech advocates claim that this couldn’t possibly be related to the feed. Since both genders eat the same amount, they argue, both would have to show the same reaction in all of their organs, etc. And if the group of animals fed with less of the GMO feed exhibit more severe reactions than the group fed the larger amount, advocates claim that this discrepancy also means that the GMOs could not be the cause, since there must always be a linear dose relationship.

The authors of this paper, however, point out that effects found in a GMO animal feeding study “cannot be disregarded on the rationale that it is not linear to the dose (or dose-related) or not comparable in genders. This would not be scientifically acceptable.” In fact, most “pathological and endocrine effects in environmental health are not directly proportional to the dose, and they have a differential threshold of sensitivity in both sexes. This is, for instance, the case with carcinogenesis and endocrine disruption.”

What’s the culprit, pesticide or plant?

The shortcomings of the feeding studies make it impossible to determine whether a particular problem is due to the added pesticide, such as Roundup residues or Bt-toxin, or due to the genetic changes in the modified plants’ DNA.

Mice fed Roundup Ready soybeans, for example, showed numerous changes indicating increased metabolic rates in the liver (i.e. irregular hepatocyte nuclei, more nuclear pores, numerous small fibrillar centers, and abundant dense fibrillar components). Since studies on Roundup herbicide also show changes in the liver cells of mice and humans, the Roundup residues within the soybeans may be a significant contributing factor to the metabolic changes.

Similarly, rats fed Roundup Ready corn showed indications that their kidneys leaked. Such an effect “is well correlated with the effects of glyphosate-based herbicides (like Roundup) observed on embryonic kidney cells.” Thus, the rats’ kidney problems may also be caused by the Roundup that is accumulated within Roundup Ready corn kernels.

In addition to the herbicide, the Bt-toxin insecticide produced inside GM corn might also cause disorders. The authors state, “The insecticide produced by MON810 [corn] could also induce liver reactions, like many other pesticides.” Studies do confirm significant liver changes in rats fed Bt corn.

On the other hand, “unintended effects of the genetic modification itself cannot be excluded” as the possible cause of these very same health problems. The process of gene insertion followed by cloning plant cells (tissue culture) can cause massive collateral damage in the plant’s DNA with potentially harmful side-effects. In MON810 corn, for example, the insertion “caused a complex recombination event, leading to the synthesis of new RNA products encoding unknown proteins.” The authors warn that “genetic modifications can induce global changes” in the DNA, RNA, proteins, and the numerous natural products (metabolites), but the faulty safety assessments are not designed to adequately identify these changes or their health impacts.

Population at risk

In addition to the shortcomings mentioned above, the paper shows how GMO feeding trials are “based on ancient paradigms” with “serious conceptual and methodological flaws,” employ statistical methods that obscure the findings, add irrelevant control groups that confuse and confound the analysis, and rely on numerous assumptions that either remain untested or have already proved false.

Unlike drug approvals, biotech companies do not conduct human studies. They would therefore fail to identify both general human health reactions, and the potentially more serious ones endured by sub-populations. “If some consumers suffer from stomach problems or ulcers,” for example, the paper states, “the new toxins will possibly act differently; the digestion in children could be affected too.” The paper recommends the implementation of post market monitoring, which, among other things, “should be linked with the possibility of detecting allergenicity reactions to GMOs in routine medicine.”

But even if authorities wanted to conduct epidemiological studies on GMOs, the authors acknowledge that they “are not feasible in America, since there is no organized traceability of GMOs anywhere on the continent.” Not only is labeling of GMOs urgently needed to allow such studies to proceed, the study says:

“The traceability of products from animals fed on GMOs is also crucial. The reason for this is because they can develop chronic diseases which are not utterly known today…. Labeling animals fed on GMOs is therefore necessary because some pesticide residues linked to GMOs could pass into the food chain.”

They also point out that “even if pesticides residues or DNA fragments are not toxic nor transmitted by themselves” nevertheless, “nobody would want to eat disabled or physiologically modified animals after long-term GMOs ingestion.”

“New experiments,” they concluded, “should be systematically performed to protect the health of billions of people that could consume directly or indirectly these transformed products.”

In the meantime, for those not willing to wait for the new studies, we recommend consulting the Non-GMO Shopping Guide at

Jeffrey M. Smith is the author of Seeds of Deception (, the world’s bestselling book on GMOs. He is also the author of Genetic Roulette (, and the Executive Director of the Institute for Responsible Technology ( The Institute’s Non-GMO Shopping Guide website (, iPhone app ShopNoGMO, and pocket guide, help people navigate to healthier non-GMO foods. Join the Institute’s Non-GMO Tipping Point Network (…) to connect with others in your area, to bring the truth about GMOs to your friends and community.


Monsanto is secretly poisoning the population with Roundup

Tuesday, October 04, 2011 by: Jeffrey M. Smith on Natural News

(NaturalNews) Dr. Andreas Carrasco remained in the locked car and watched with fear as the crowd beat the vehicle and shouted at him — for two hours. His friends who didn’t make it into the vehicle were not so lucky. One ended up paralyzed. Another unconscious. The angry crowd of about 100 were likely organized by a local rice grower who was furious at Carrasco for what he was trying to do that day. Carrasco’s crime? Telling people that Roundup herbicide from Monsanto causes birth defects in animals, and probably humans.

Carrasco is a leading embryologist at the University of Buenos Aires Medical School and the Argentinean national research council. He had heard the horrific stories of peasant farmers working near the vast fields of Roundup Ready soybeans — plants genetically engineered to withstand generous doses of Monsanto’s poisonous weed killer. The short-term impact of getting sprayed was obvious: skin rashes, headaches, loss of appetite, and for one 11 year old Paraguayan boy named Silvino Talavera, who biked through a fog of herbicides in 2003, death. But Carrasco also heard about the rise of birth defects, cancer, and other disorders that now plagued the peasants who were sprayed by plane. He decided to conduct a study.

Exposing Roundup’s 30 year cover-up of birth defects

Carrasco injected minute amounts of Roundup into chicken and frog embryos, and sure enough, the offspring exhibited the same type of birth deformities that the peasant communities were seeing in their newborns. A report by the provincial government of Chaco soon followed, confirming that those living near soy and rice fields sprayed with Roundup and other chemicals did in fact have higher rates of birth defects — nearly a fourfold increase between 2000-2009. (Child cancer rates tripled during the same period.)

Regulatory agencies had given Roundup a green light years before, claiming that it was free of such problems. However after Carrasco’s findings were published, European authorities quietly pushed their official re-assessment of Roundup, due in 2012, back to 2015. And the German Federal Office for Consumer Protection and Food Safety, charged with responding to Carrasco’s findings, issued a statement claiming that the Argentine scientist must be mistaken; earlier studies conducted by manufacturers of Roundup (including Monsanto) had already demonstrated that Roundup does not cause birth defects.

But in June 2011, a group of international scientists released a report detailing a massive cover-up that went back to the 1980s. The very industry studies cited by the German Consumer Protection office in fact showed just the opposite. Roundup did increase birth defects. Using scientific sleight of hand, Europe’s regulators had ignored statistically significant increases in birth defects, and so did every other regulatory agency worldwide. Monsanto has relied on these misleading statements of safety by regulators ever since, using them to deny that Roundup causes birth defects.

Monsanto secretly poisoning the population, again and again

Covering up toxic effects of their products was not new for Monsanto. They’re experts at it. In 2003 the company paid $700 million in settlements for secretly poisoning the population living next to their PCB factory in Anniston, Alabama. Court documents showed the arrogance of Monsanto executives made aware of the product’s effects: “We can’t afford to lose $1 of business,” was the written response in a secret company memo.

Leaked documents also revealed that EPA scientists had charged Monsanto with fraudulently hiding the toxic effects of Agent Orange — effectively preventing Vietnam veterans from collecting compensation for cancer, birth defects, and other symptoms of exposure.

When Carrasco first reported his findings, he got the usual treatment. His results were vehemently denied, and he was attacked in the press by biotech advocates. Four highly aggressive men showed up at his office and tried to interrogate him, but he wasn’t physically attacked. Not until he tried to give a speech on his results in the small Argentine farm town of La Leonesa on August 7, 2010. That was unusual.

Punishing messengers worldwide

When Dr. Irina Ermakova came to her office, the meaning of the charred remains of papers on her desk was unambiguous — it was yet another attempt to intimidate or punish her. So was the theft of samples from her laboratory, and the continuous verbal attacks by biotech advocates. Her crime? She fed rats genetically modified Roundup Ready soy, and reported the results.

Those results were clearly not what the sellers of GM soy wanted us to hear. After female rats were fed GM soy, more than half their babies died within three weeks. The rat pups were also considerably smaller, and in a later experiment, were unable to reproduce. Offspring from mothers fed non-GM soybeans, on the other hand, died at only a 10% rate, and were able to mate successfully.

Journal ambushes scientist

After Ermakova presented the results as “preliminary” at an October 2005 conference, the biotech industry’s damage control teams kicked into high gear. At the center of the coordinated attack was the editor of the journal Nature Biotechnology and four biotech advocates. According to Ermakova, the editor contacted her and told her he was going to include a description of her study as a sort of essay in the journal. She was then asked to summarize her research over the phone, or if she preferred, in writing. Ermakova, a senior scientist at the Russian Academy of Sciences, was surprised by the request and asked instead to properly submit the findings for peer review and publication. Oh no, the editor insisted, he just wanted a summary. She sent it in, and the journal sent Ermakova back a proof of the article, with her named as the author.

But that was just a “dummy proof.” What was actually published was quite different. Instead of an essay, the journal had inserted scathing criticisms from the four biotech advocates after nearly every paragraph. Many of Ermakova’s citations were also stripped off and replaced with those chosen by the biotech detractors — to weaken her case. It was an academic lynch mob, conducted by four biotech apologists: Bruce Chassy, Vivian Moses, Val Giddings, and Alan McHughen. All acknowledged that they had no personal experience in the type of research they were condemning, but that didn’t stop them from throwing every type of challenge they could think of at Ermakova.

The purpose of the attack was transparent. It allowed the biotech industry to claim from that point forward that the study showing high death rates was officially refuted and discredited. It also served as a warning: if anyone wanted to defend Ermakova (or do similar research) they too would be mercilessly attacked.

The problem was that nearly all their criticisms were utterly baseless. About 75 % of their arguments, for example, were simply complaints that she didn’t provide sufficient detail. Now remember — she was told to only provide a summary. Her request to the editor to submit complete details was denied. It was quite a setup. When the details of this ambush were made public, independent scientists charged Nature Biotechnology with an unethical “premeditated attack.” At least one letter called on the editor to resign.

It didn’t happen. Instead, international pressure against Ermakova got so intense, her boss told her not to do any more studies on GMOs. One of her colleagues even tried to comfort her by suggesting that perhaps the GM soy could solve the human overpopulation problem. (She wasn’t comforted.)

Real life confirms research: GM soy = high infant mortality for rats

The main valid criticism against Ermakova’s research was that she failed to conduct a biochemical analysis of the feed. Without that, we don’t know if some rogue toxin present in the bag of soy flour might have been responsible for the astonishing death rate and stunted growth in her experiment. But subsequent events at her laboratory suggest otherwise.

After Ermakova repeated the test three times with similar results, the supplier of rat food used at the facility began using GM soy in the formulation. With all the rats now eating GM soy, Ermakova couldn’t conduct any more experiments (she had no controls). After two months, however, she asked her colleagues at the lab about the mortality rate in their rat experiments. It turned out that 99 of 179 (55.3%) rat pups whose parents were fed GM soy-based rat chow had died within the first 20 days. Thus, whatever caused the high death rate does not appear to be confined to the one batch of GM flour used in her experiment. Both the study, and the subsequent laboratory-wide mortality rate, are published in the Russian peer-reviewed journal Ecosinform.

Horrific reproductive disorders

Other studies on Roundup Ready soy also show scary reproductive problems. Ermakova showed that the testicles of rats fed GM soy changed from the normal pink to blue (not published). Peer-reviewed research from Italy also showed changes in mice testicles, including alterations in young sperm cells. A Brazilian team found changes in the uterus and ovaries of female rats. The DNA of mice embryos functioned differently, compared to those whose parents were fed non-GM soy. And when hamsters were fed GM soy for two years, by the third generation, most lost the ability to have babies. The offspring grew at a slower rate and the infant mortality rate was 4-5 times that of the non-GM soy group. Many also had hair growing in their mouths.

When the Austrian government tested Roundup Ready corn (which was also engineered to produce an insecticide), mice had fewer – and smaller – babies.

It’s not possible to know if the reproductive damage was due to the genetic changes in the GM crops, the high residues of Roundup in the GM soybeans and corn, or some other reason. But the American Academy of Environmental Science is among the medical organizations that don’t need more animal studies before issuing a warning. They urge all doctors to prescribe non-GMO diets to everyone.

Omnipresent Roundup literally falls from the sky

Although eliminating Roundup Ready soy and corn from our diet will certainly reduce our intake of Roundup, a recent study suggests that getting our exposure down to zero is not possible. In the Midwest during the growing season, Roundup is found in 60–100% of air and rain samples, as well as in streams.

The omnipresence of Roundup in the US is due in large part to the more than 100 million acres of Roundup Ready crops. As farmers pour on Monsanto’s weed killer, weeds are learning to adapt and withstand the poison — so farmers pour on more. In the first 13 years since GM crops were introduced, the use of herbicide-tolerant crops resulted in an additional 383 million pounds more herbicide. And due to the emergence of superweeds (now found in 11 million acres), the increased use of Roundup is accelerating dramatically.

USDA solution? Even more Roundup

The USDA has a unique response to this mounting threat: Add more Roundup. In January 2011 they deregulated yet another Roundup Ready crop, alfalfa — which is widely used for animal feed. Only 7% of the more than 20 million acres of this crop typically gets any herbicide applied to it. But that’s about to change, since Roundup Ready alfalfa will soon be drinking Roundup in a hay field near you.

Not content with just the alfalfa, on July 1 the USDA told Scotts Miracle-Gro that it could introduce Roundup Ready Kentucky Bluegrass to lawns, golf courses, and soccer fields around the nation, without any government oversight.

So now we have Roundup in our food, animal feed, air, rain, and streams, and soon it will be sprayed in high doses where our children play on the grass. It’s not just birth defects that may soon plague America as a result. Roundup is also linked to cancer, endocrine disruption, lower sperm counts, abnormal sperm, human cell death, miscarriages, and other disorders. But it’s also linked to billions in profits for Monsanto. No wonder they are working overtime to silence the scientists and cover-up the findings. What if people knew the truth?

Jeffrey M. Smith is the author of Seeds of Deception (, the world’s bestselling book on GMOs. He is also the author of Genetic Roulette (, and the Executive Director of the Institute for Responsible Technology ( The Institute’s Non-GMO Shopping Guide website (, iPhone app ShopNoGMO, and pocket guide, help people navigate to healthier non-GMO foods. Join the Institute’s Non-GMO Tipping Point Network (…) to connect with others in your area, to bring the truth about GMOs to your friends and community.

The new PCB: Monsanto’s Roundup weed killer turning up in air, rain and rivers

Tuesday, September 27, 2011 by: Ethan A. Huff, Natural News staff writer

(NaturalNews) Last month, the US Geological Survey (USGS) released a report showing that air, rainwater and rivers across the Midwest US agricultural belt are routinely contaminated with high levels of glyphosate, a pervasive herbicide produced by biotechnology giant Monsanto. And according to some, Monsanto has likely known about this for some time, but chosen to hide it from the public.

After two years of gathering and analyzing environmental samples, USGS scientists determined that the more than 180 million pounds of glyphosate spread on conventional and genetically-modified (GM) crops every year is causing “significant” environmental contamination.

Certain that Monsanto is hiding its own critical information about Roundup, Ken Cook, president of the consumer advocacy organization Environmental Working Group (EWG), has written an open letter to Hugh Grant, chairman and president of Monsanto, petitioning him to immediately release any and all studies the company is hiding about the herbicide.

“Monsanto notoriously hid PCB (polychlorinated biphenyl) contamination in Alabama for decades,” said Cook, referring to the infamous Monsanto PCB scandal where a plant producing the chemical from 1929 to 1972 ended up turning the entire town of Anniston, Ala., into a type of toxic waste zone — and PCB is still showing up around the area to this day (

“We are asking that in this case, [Monsanto] tell the public what it knew about glyphosate contamination, and when it knew. It is inconceivable that a company with Monsanto’s scientific capacity did not predict, and examine, the possibility of air and water contamination by glyphosate.”

Back in the summer, it was revealed that Monsanto knew glyphosate caused birth defects, endocrine disruption, DNA damage, reproductive and developmental toxicity, neurotoxicity, and cancer. This was discovered in many of its own scientific studies. But according to reports, the company knowingly withheld this crucial information from the public, and from government officials, in order to keep the product on the market (

So is it unreasonable, then, to assume that Monsanto is aware of, but withholding, critical data proving that glyphosate permeates into the deepest corners of the natural environment upon extensive use, contaminating everything in its path? Cook appears to think so, and we tend to agree with him.

You can read Cook’s full letter to Monsanto’s Grant here:…