Scientific studies conclude GMO feed causes organ disruption in animals

Wednesday, October 05, 2011 by: Jeffrey M. Smith – Natural News

(NaturalNews) A new paper reviewing data from 19 animal studies shows that consuming genetically modified (GM) corn or soybeans leads to significant organ disruptions in rats and mice, particularly in livers and kidneys (http://www.enveurope.com/content/23/1/10). “Other organs may be affected too, such as the heart and spleen, or blood cells,” stated the paper. In fact some of the animals fed genetically modified organisms had altered body weights, which is “a very good predictor of side effects in various organs.”

The GM soybean and corn varieties used in the feeding trials “constitute 83% of the commercialized GMOs” that are currently consumed by billions of people. While the findings may have serious ramifications for the human population, the authors demonstrate how a multitude of GMO-related health problems could easily pass undetected through the superficial and largely incompetent safety assessments that are used around the world.

The researchers, lead by French Professor Gilles-Eric Seralini, found that nearly 1 out of every 10 measured parameters in the studies, including blood and urine biochemistry, organ weights, and microscopic analyses, were significantly disrupted in the animals fed GMOs. The kidneys of males fared the worst, with 43.5% of all the changes. The liver of females followed, with 30.8%. The report, published in Environmental Sciences Europe on March 1, 2011, confirms that “several convergent data appear to indicate liver and kidney problems as end points of GMO diet effects.” The authors point out that livers and kidneys “are the major reactive organs” in cases of chronic food toxicity.

Feed’em longer!

One of the most glaring faults in the current regulatory regime is the short duration of animals feeding studies. The industry limits trials to 90 days at most, with some less than a month. Only two studies reviewed in this new publication were over 90 days — both were non-industry research.

Short studies could easily miss many serious effects of GMOs. It is well established that some pesticides and drugs, for example, can create effects that are passed on through generations, only showing up decades later. IN the case of the drug DES (diethylstilbestrol), “induced female genital cancers among other problems in the second generation.” The authors urge regulators to require long-term multi-generational studies, to “provide evidence of carcinogenic, developmental, hormonal, neural, and reproductive potential dysfunctions, as it does for pesticides or drugs.”

Pesticide Plants

Nearly all GM crops are described as “pesticide plants.” They either tolerate doses of weed killer, such as Roundup, or produce an insecticide called Bt-toxin. In both cases, the added toxin — weedkiller or bug killer — is found inside the corn or soybeans we consume.

When regulators evaluate the toxic effects of pesticides, they typically require studies using three types of animals, with at least one feeding trial lasting 2 years or more. One third or more of the side effects produced by these toxins will show up only in the longer study — not the shorter ones. But for no good reason, regulators ignore the lessons learned from pesticides and waive the GM crops-containing-pesticides onto the market with a single species tested for just 90 days. The authors affirm that “it is impossible, within only 13 weeks, to conclude about the kind of pathology that could be induced by pesticide GMOs and whether it is a major pathology or a minor one. It is therefore necessary to prolong the tests.”

GMO approvals also ignore the new understanding that toxins don’t always follow a linear dose-response. Sometimes a smaller amount of toxins have greater impact than larger doses. Approvals also overlook the fact that mixtures can be far more dangerous than single chemicals acting alone. Roundup residues, for example, have been “shown to be toxic for human placental, embryonic, and umbilical cord cells,” whereas Roundup’s active ingredient glyphosate does not on its own provoke the same degree of damage. One reason for this is that the chemicals in Roundup “stabilize glyphosate and allow its penetration into cells.”

Furthermore, toxins may generate new substances (metabolites) “either in the GM plant or in the animals fed with it.” Current assessments completely ignore the potential danger from these new components in our diets, such as the “new metabolites” in GMOs engineered to withstand Roundup. The authors warn, “We consider this as a major oversight in the present regulations.”

“It’s not the same stuff that farmers spray”

Regulators claim that the Bt-toxin produced inside GM corn is safe. They say that the Bt gene comes from soil bacteria Bacillus thuringiensis (Bt), which has been safely applied as a spray-on insecticide by farmers in the past. But the authors insist that “the argument about ‘safe use history’ of the wild Bt protein . . . Cannot, on a sound scientific basis, be used for direct authorizations of . . . GM corns,” without conducting proper long-term animal feeding studies.

In order to justify their claim that the wild Bt-toxin is safe, the authors state that it must first be separately tested on animals and humans and then authorized individually for food or feed, which it has not. And even if the wild variety had been confirmed as safe, the GM versions are so different, they must require their own independent studies. The paper states:

“The Bt toxins in GMOs are new and modified, truncated, or chimerical in order to change their activities/solubility in comparison to wild Bt. For instance, there is at least a 40% difference between the toxin in Bt176 [corn] and its wild counterpart.”

Even though the isolated Bt-toxin from GM corn has not been tested on animals, rodent studies on corn containing the toxin do show problems. Male rats fed Monsanto’s MON863 corn, for example, had smaller kidneys with more focal inflammation and other “disrupted biochemical markers typical of kidney filtration or function problems.”

Stop with the dumb excuses

If statistically significant problems show up in their studies, biotech company researchers often attempt to explain away the adverse findings. But the authors of this review paper describe their excuses as unscientific, obsolete, or unjustified.

When male and female animals have different results, for example, biotech advocates claim that this couldn’t possibly be related to the feed. Since both genders eat the same amount, they argue, both would have to show the same reaction in all of their organs, etc. And if the group of animals fed with less of the GMO feed exhibit more severe reactions than the group fed the larger amount, advocates claim that this discrepancy also means that the GMOs could not be the cause, since there must always be a linear dose relationship.

The authors of this paper, however, point out that effects found in a GMO animal feeding study “cannot be disregarded on the rationale that it is not linear to the dose (or dose-related) or not comparable in genders. This would not be scientifically acceptable.” In fact, most “pathological and endocrine effects in environmental health are not directly proportional to the dose, and they have a differential threshold of sensitivity in both sexes. This is, for instance, the case with carcinogenesis and endocrine disruption.”

What’s the culprit, pesticide or plant?

The shortcomings of the feeding studies make it impossible to determine whether a particular problem is due to the added pesticide, such as Roundup residues or Bt-toxin, or due to the genetic changes in the modified plants’ DNA.

Mice fed Roundup Ready soybeans, for example, showed numerous changes indicating increased metabolic rates in the liver (i.e. irregular hepatocyte nuclei, more nuclear pores, numerous small fibrillar centers, and abundant dense fibrillar components). Since studies on Roundup herbicide also show changes in the liver cells of mice and humans, the Roundup residues within the soybeans may be a significant contributing factor to the metabolic changes.

Similarly, rats fed Roundup Ready corn showed indications that their kidneys leaked. Such an effect “is well correlated with the effects of glyphosate-based herbicides (like Roundup) observed on embryonic kidney cells.” Thus, the rats’ kidney problems may also be caused by the Roundup that is accumulated within Roundup Ready corn kernels.

In addition to the herbicide, the Bt-toxin insecticide produced inside GM corn might also cause disorders. The authors state, “The insecticide produced by MON810 [corn] could also induce liver reactions, like many other pesticides.” Studies do confirm significant liver changes in rats fed Bt corn.

On the other hand, “unintended effects of the genetic modification itself cannot be excluded” as the possible cause of these very same health problems. The process of gene insertion followed by cloning plant cells (tissue culture) can cause massive collateral damage in the plant’s DNA with potentially harmful side-effects. In MON810 corn, for example, the insertion “caused a complex recombination event, leading to the synthesis of new RNA products encoding unknown proteins.” The authors warn that “genetic modifications can induce global changes” in the DNA, RNA, proteins, and the numerous natural products (metabolites), but the faulty safety assessments are not designed to adequately identify these changes or their health impacts.

Population at risk

In addition to the shortcomings mentioned above, the paper shows how GMO feeding trials are “based on ancient paradigms” with “serious conceptual and methodological flaws,” employ statistical methods that obscure the findings, add irrelevant control groups that confuse and confound the analysis, and rely on numerous assumptions that either remain untested or have already proved false.

Unlike drug approvals, biotech companies do not conduct human studies. They would therefore fail to identify both general human health reactions, and the potentially more serious ones endured by sub-populations. “If some consumers suffer from stomach problems or ulcers,” for example, the paper states, “the new toxins will possibly act differently; the digestion in children could be affected too.” The paper recommends the implementation of post market monitoring, which, among other things, “should be linked with the possibility of detecting allergenicity reactions to GMOs in routine medicine.”

But even if authorities wanted to conduct epidemiological studies on GMOs, the authors acknowledge that they “are not feasible in America, since there is no organized traceability of GMOs anywhere on the continent.” Not only is labeling of GMOs urgently needed to allow such studies to proceed, the study says:

“The traceability of products from animals fed on GMOs is also crucial. The reason for this is because they can develop chronic diseases which are not utterly known today…. Labeling animals fed on GMOs is therefore necessary because some pesticide residues linked to GMOs could pass into the food chain.”

They also point out that “even if pesticides residues or DNA fragments are not toxic nor transmitted by themselves” nevertheless, “nobody would want to eat disabled or physiologically modified animals after long-term GMOs ingestion.”

“New experiments,” they concluded, “should be systematically performed to protect the health of billions of people that could consume directly or indirectly these transformed products.”

In the meantime, for those not willing to wait for the new studies, we recommend consulting the Non-GMO Shopping Guide at www.NonGMOShoppingGuide.com

Jeffrey M. Smith is the author of Seeds of Deception (http://www.seedsofdeception.com/Public/Home/index.cfm), the world’s bestselling book on GMOs. He is also the author of Genetic Roulette (http://www.geneticroulette.com), and the Executive Director of the Institute for Responsible Technology (http://www.responsibletechnology.org). The Institute’s Non-GMO Shopping Guide website (http://www.nongmoshoppingguide.com), iPhone app ShopNoGMO, and pocket guide, help people navigate to healthier non-GMO foods. Join the Institute’s Non-GMO Tipping Point Network (http://action.responsibletechnology.org/p/salsa/web/common/public/sig…) to connect with others in your area, to bring the truth about GMOs to your friends and community.

 

The European Court of Justice has decided: Bees or GMOs?

Wednesday 07 September 2011 on Bee Life

The European Court of Justice today provided its judgement: Beekeeping products contaminated with pollen derived from GM crops are considered “products derived from GMOs”

We now face a profound dilemma: Do we just automatically accept that all honey and pollen is now contaminated with GM products? Or do we demand legislation which orders that safe distances or quarantine zones must be imposed to protect bees and apiaries from toxic GM crops?

In 2005, the honey of an amateur beekeeper, Mr Bablok, from the German region of Bavaria, was found to be contaminated with GM pollen, derived from Bt corn fields (MON810) that this region was testing. According to European legislation (Regulation (EC) 1829/2003), any food-product containing GM material must go through an approval process to prove it is safe for consumers.

Since Mr Bablok believed that the GM test-crops had contaminated his honey with GM material and GM toxins, he initiated legal proceedings before the German Court of Justice. The European Court of Justice has now asserted three critical findings in its judgement, of September 6th 2011, namely:

  1. Pollen derived from GM crops, that is found in the beehive, is not considered a GM organism (GMO)
  2. Beekeeping products containing pollen derived from GM crops are considered as “produce from GMOs”
  3. The presence of GM material in honey, pollen and beekeeping products cannot be tolerated, it is illegal.

Farming was practised in a sustainable manner for centuries, until the arrival of industrialised and chemicalised farming post WWII. Along with industrial farming and monocultures, tools to control pests were developed, such as GMOs, or various forms of pesticide application (e.g. seed or soil treatments). However, the implications for our health, wildlife and our environment remain still unclear.

Recent scientific studies have proved that systemic pesticides and GM plant toxins inflict poisonous effects on the nervous systems of bees[1] and other possible toxic effects on beneficial insects like butterflies and ladybirds[2]. The pollen that Mr Bablok collected from his hives contained both genetic material from GM maize and Bacillus Thuringiensis (Bt) toxins with insecticidal properties. Therefore, quite apart from the problem that this may pose for consumers, this pollen may prove toxic for bees and other wildlife.

For many years, politicians and regulators have been unwilling to address the problem of coexistence between GM crops and traditional agriculture. But this has now come to a crisis point with beekeeping; the agricultural sector that is crucial for the pollination of a great part of human food-crops.

Bees visit flowers to harvest nectar and pollen, from which they make the honey and pollen which we consume. It is impossible to restrict the areas and flowers which the bees visit, and consequently, if the planting of GM crops in Europe increases, GM pollen and plant toxins will increasingly be found in honey and pollen.

In Europe, however, it may still be possible to avoid this problem, because the area of land planted with GM is relatively small (in Bulgaria, Romania and Spain), despite suspicions of unauthorised GMO farming in some EU member states[3]. The situation is infinitely worse in other countries like USA, Canada, China, Argentina, Brazil or India, where GM crops are now ‘the norm’ rather than the exception. In America for example, over 92 million acres were planted with GM Maize, treated with systemic neonicotinoid pesticides in 2010.

The consequences for the market are undeniable; this is a disaster for beekeepers, for honey producers and for the whole of agriculture.

Europe’s beekeeping industry will clearly be devastated as a result of this judgement. Until last week, Honey and pollen commanded a high retail value, because it was seen as good for people’s for health and wellbeing; it may now be regarded as injurious to people’s health and wellbeing. Beekeepers, cannot possibly control where their bees forage or which crops they visit, and will now be forced to prove that their products have not been contaminated with GM material. Laboratory tests will now be needed on every batch of honey and pollen, to certify that they are “GM free”. This will involve huge financial costs for both large and small beekeepers and will drive the majority of the 600.000 beekeepers in Europe from the market, since small-producers will not be able to bear such financial costs.

Those beekeepers who do manage to remain in business, despite the extra costs of the “GM free” certification, will face dramatically increased costs of production and as a result they will be forced to increase the retail price for consumers.

Lab photo (lab-picture.jpeg) If laboratory tests reveal that there is GM content in the honey and pollen, beekeepers (who cannot possibly avoid contamination), will be forced to market their products with the label “produced from GMOs”. This would prove to be a massive marketing handicap and would probably make their products unsaleable, if not completely worthless.

The European Union imports 40% of all the honey it consumes and the EU countries mentioned above, where GMOs are planted and used, account for at least 20% of EU honey production. The decision of the Court implies the withdrawal from the European market of approximately 50-60% of existing honey, which will cause consumer prices to soar. This could deliver a fatal blow to the entire market for beekeeping products in Europe, since the the average consumer will view them with great suspicion.

The opinion of the Court of Justice has made it clear: GM pollen in agricultural products equals the end for beekeeping products.

It is time for European consumers and politicians to make a decision: Do we want GMOs and GM toxins in our food, or do we want healthy bees, wholesome honey and pollen and bee-products which are free from GMOs?

Notes

[1] Ramirez-Romero R.; Desneux N.; Decourtye A.; Chaffiol A.; Pham-Delègue M.H. (2008) Does Cry1Ab protein affect learning performances of the honey bee Apis mellifera L. (Hymenoptera, Apidae)? Ecotoxicol Environ Saf. 70:327-33

[2] http://independentsciencenews.org/n…

[3] http://www.naturalnews.com/033098_H…

 

Response to “Some truth about GMO” by Mr. Wilmot Simmons

— 04 November 2011 — by Naud Brouwer

Dear Editor,

The use of BT in organic farming is a fact; the thing is that organic farmers have used BT as a pesticide, sprayed on their crops so the UV light from the sun can break it down, and the rain could wash the BT off before any product would be harvested.

Another interesting thing is that the BT used by organic farmers for over 50 years is a weakened or almost dead bacteria. This is only sprayed in case of high insect infestation and only onto the affected area. The bacterium inside the spray contains the pro-form of the so- called BT toxin.

This is not an active component; it needs to be tailored (cut to size) to produce the active BT toxin, which is effective as a pesticide.

When the insect eats the dead bacterium, the toxin is partially digested in the insect gut by proteolytic (cutting) enzymes and converted to active BT toxin. This is actually a lectin which binds to the gut wall of the insects and this interferes with the digestion/absorption of food, thereby preventing growth, maturation, reproduction.

The actual bacterium, which is not eaten by any insects, degrades in the light/sun/rain pretty fast (less than a day). The chances of pests developing resistance to it are very low indeed, since all the pests which are exposed to the toxin are affected by it.

NOTE! The ACTIVE TOXIN can only be found IN THE GUT OF THE INSECT. (Susan Pusztai Bt in organic
farming and GM crops – the difference)

The BT produced by BT corn however, does contain high doses of the active toxin, in the whole plant. The toxin cannot be washed off, or broken down by the sunlight. It stays in the plant after harvesting. The rest material of the plant breaks down, and the BT toxin gets into the ground, and the groundwater. Because of the constant exposure to BT toxin the pests that the farmers want to control develop a resistance to the BT itself, and this means that farmers will have to start spraying even more pesticides than they had to do before with their conventional Hybrid seed.

Is BT corn safe to eat? There has not been any long term testing on humans, so we simply do not know. We do know that:

• BT is extremely similar (so much so it is difficult to distinguish without sophisticated testing) to two other bacteria: B. cereus, which causes food poisoning, and B. anthracis, which causes anthrax.

• BT secretes many of the same toxins B. cereus does when it is growing. There is mounting evidence that spores germinate in humans and can live for extended periods of time in the respiratory and gastrointestinal tract. The effect of these low level infections is unknown, but there have been isolated reports of disease caused by BT. One of the reasons BT may not be seen as a common cause of sickness is that it is very hard to test for its presence – many cases diagnosed as B. cereus gastroenteritis (a fairly common form of food poisoning) may in fact be caused by BT.

• People with sensitive immune systems could be affected in ways we do not yet know, but immune responses are seen when BT infections establish in humans.
• DDT was used for thirty years and was claimed to be extremely safe for humans. The same sort of testing done to arrive at that conclusion has been
done with BT. (Quick Bt Facts)

“Lower crop production”

I am not aware of anyone saying that there will be a lower crop production. But I do know from scientific research that the promised higher yields are not as promising as the big companies tell us.

I would like you to read “failure to yield” written by the Union of Concerned Scientists.

“The U.S. Department of Agriculture data indicate that the average corn production per acre nationwide over the past five years (2004–2008) was about 28 percent higher than for the five-year period 1991–1995, an interval that preceded the introduction of BT varieties.

But our analysis of specific yield studies concludes that only 3–4 percent of that increase is attributable to BT, meaning an increase of about 24–25 percent must be due to other factors such as conventional breeding.”

Failure to yield

Another interesting research on higher yields is a study performed over 30 years.

“Organic farming is far superior to conventional systems when it comes to
building, maintaining and replenishing the health of the soil. For soil health alone, organic agriculture is more sustainable than conventional.

When one also considers yields, economic viability, energy usage, and human health, it’s clear that organic farming is sustainable, while current conventional practices are not.”

FST 30 Years

Since I am writing a letter to the editor of a newspaper and not a book, I have to leave it at this for now. I do want to challenge Mr. Simmons to come up with some unbiased (not paid for by any of the big GMO companies) research about all the issues there are about GMO corn. And I want him to convince me that there is nothing to worry about.

Naud Brouwer
San Miguel, Toledo

 

Dear Reader,

Here in the Mid-Atlantic, we’re approaching the end of sweet corn season. For at least two or three more weeks we’ll be seeing plenty of corn available at roadside stands, framers markets and most grocery stores. So get it while you can, because it will soon be gone. But be on the safe side, pass on the stuff piled in produce bins at your local store because there’s a very good chance it’s Frankencorn and I’m sorry to report that  It’s Alive, ALIVE!
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